Description
Macrophage Inflammatory Protein-1 (MIP-1,alpha) is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1& alpha affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1,alpha also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1,alpha is composed of 69 aa residues with not possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1,alpha is 60% homologous with human MIP-1, alpha, 75% homologous with murine MIP-1,alpha, and has been shown to be active on murine cells